First off, I think completely synthetic nanotechnology is a dead end. It will never be as good as what we already have available in genetic engineering. Why reinvent the wheel?
Second, OK, I'll play this game. Assuming that some miracle drug or technology comes along that extends our lives by... let's just say 500 years. Damn, I would have a ball with that. There's so many things I could actually concentrate on mastering that I don't have to bounce from one to the next in just a couple of years. Methusalean longevity is what you make of it. If all you ever want to do is play video games for half your live, then that's what you will do even if your life is 500 years. For people like myself, there's a million things we can do and it would only take a sacrifice of 100 years to establish ourselves finanacially. After that, it's 300 years of college and other training for all the things I want to do. Damn, I should be so lucky.
As for being risk adverse, I don't know very many teens who think about their own mortality. So I seriously doubt that any would even if they have 500 years to go. Only those 'middle aged' would consider their mortality. But then, they do already. Again, it's a matter of personality. I imagine there's a lot of thrillseekers who, after a few hundred years, end up so jaded that unless they're massively risking their lives, they won't feel a thing.
Eccentricity? People are eccentric now. I agree, people will get more set in their ways. After a few hundred years, they're likely to be quite unusual - and perhaps wise too.
Boredom? Shit, there's far too much to explore to be bored. But then, if the extent of your interests is playing video games, then I can imagine one getting bored. Again, the answer lies entirely in the personality, not the world.
Things will slow down? Not a chance - some people will, some people won't. Again it's personal choice and personality that matters more than external conditions. People might have to learn to be more patient. But others will just take it to mean they have 400 more years to rule the world. And they just can't wait to get started.
What Richard Dawkins proposes will take dozens if not hundreds of generations before it bears any noticeable results. The human body is optimized to peak in the teens and twenties and decline after that. We can almost double one's lifespan simply by blocking insulin use within our fat cells. (
Source) But there's a whole lot of factors involved; not just insulin. It's not just the genes that unravel; growth regulation, the immune system, environmental damage, etc., all play a role in the aging process. It's possible to double our lifespans by altering our genes at the blastocyst stage of development. But beyond that, genetics takes a back seat to environment as the leading cause of damage.